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KMID : 0370920120290020096
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Yeungnam Univercity Journal of Medicine
2012 Volume.29 No. 2 p.96 ~ p.101
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Long-Term Complete Remission in an Acute Myeloid Leukemia Patient with Isolated Central Nervous System Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
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Kim Myung-Jin
Koh Sung-Ae
Jang Hyo-Jin
Jeong Da-Eun
Park Jung-Min
Lee Kyoung-Hee
Kim Min-Kyoung
Bae Young-Kyung
Hyun Myung-Soo
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Abstract
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Allogeneic hematopoietic stem cell transplantation (HSCT) is considered the optimal curative treatment for acute myeloid leukemia (AML), but some patients develop bone marrow relapse due to remnant leukemia, and few patients develop extramedullary relapse without bone marrow relapse. Isolated extramedullary relapse (IMER) is defined as extramedullary relapse without bone marrow relapse. IMER has been reported in various sites, including the skin, soft tissue, and central nervous system(CNS). Isolated CNS relapse is relatively rare and is associated with poor prognosis due to the absence of an optimal treatment for it. Reported herein is a case involving an adult AML woman who suffered from isolated extramedullary relapse in the CNS after allogeneic HSCT. She was treated with intrathecal chemotherapy and whole-brain and spine radiotherapy, followed by systemic chemotherapy. She is currently well, with no evidence of leukemia recurrence for over six years.
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KEYWORD
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Meningeal carcinomatosis, Leukemia, Central nervous system, Bone marrow transplantation
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